Aging of the Genome: the dual role of DNA in life and death [Paperback]

Jan Vijg (Author)

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Product Details

Paperback: 384 pages
Publisher: Oxford University Press; 1 edition (April 5 2007)
Language: English
ISBN-10: 0198569238
ISBN-13: 978-0198569237
Product Dimensions: 24.2 x 18.8 x 2.4 cm
Shipping Weight: 862 g
Amazon Bestsellers Rank: #1,499,571 in Books (See Top 100 in Books)

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Review

'This is a work of real scholarship...'Nature, Vol 447, 17 May 2007.

Book Description

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

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Science and technology extend life and improve the quality of life. Read the first page

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