Regenerative medicine is a highly interdisciplinary field, with contributions from medicine, engineering, and chemistry. Chemical biology plays a key role – small molecules are involved in differentiating, reprogramming and manipulating stem cells and in enabling transplantation.
In Chemical Biology in Regenerative Medicine, an international team of experts provides an overview of progress towards clinical application in the areas of transplantation (allogenic and autologous), manipulation of niche environment and homing, and cell reprogramming (trans-differentiation and de-differentiation). The book highlights the interdisciplinary approaches undertaken to resolve current technical problems in regenerative medicine, with special attention paid to small molecules and biomaterials engineering. It also includes an overview of the current regulatory climate and discusses the future of these therapies. Topics covered include:
- Wnt Signaling in Regulation of Stem Cells
- Directed Cardiomyogenesis of Pluripotent Stem Cells
- Chemical Genetics in Cardiomyocyte Generation
- Challenges and New Directions for Cardiac Reprogramming
- Comparative Analysis of Adult Stem Cell Niches
- Chemicals and Stem Cells for Promoting Regeneration
- Chemically Induced Pluripotent Stem Cells (CiPSC): A Potential Chemical Biological Breakthrough in Reprogramming?
- An Introduction to Cellular Reprogramming: The Plasticity of Cell Fates and Identities
- Chemicals Facilitating Reprogramming
- Chemicals Facilitating Reprogramming: Targeting the SAM Binding Site to Identify Novel Methyltransferase Inhibitors
- Biomaterials for Directed differentiation
Chemical Biology in Regenerative Medicine is an essential overview of this emerging technology for researchers in academia, industry and clinical settings working in regenerative medicine, chemical biology, biochemistry, cell biology, biomaterials and bioengineering.