This show is absolutely freaking hilarious. It's too bad it came out in the same year as the writer's strike, but even so, the writers managed to produce an awesome albeit shortened season.
Chuck Bartowsky was kicked out of Stanford 4 years ago by his best friend - turned arch enemy Bryce Larkin. Fast forward 4 years and Bryce is a rogue CIA agent who has stolen the combined files from the CIA and NSA, termed the Intersect. He was shot and killed while destroying the Intersect, but not before he sent all of the Intersect's data, encoded in pictures, to Chuck Bartowsky, the one person who can retain the subliminal information.
Chuck, now a supervisor for the Nerd Herd at the Buy More (Think FutureShop or Best Buy), has all the secrets of two governement agencies locked in his brain. The busty blonde agent Sarah from the CIA goes undercover as Chuck's girlfriend while the disciplined agent Casey of the NSA becomes a salesman at the Buy More in order to work together and protect the Intersect. Trouble doesn't seem to find Chuck however, Chuck seems to find trouble.
All in all, a very enjoyable first season that just gets better and better as things progress. I highly recommend this to anyone who enjoys a witty, light-hearted comedy.