Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors [Hardcover]

Eric Wickstrom (Editor)

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Product Details

Hardcover: 448 pages
Publisher: CRC Press; 1 edition (April 21 1998)
Language: English
ISBN-10: 0824700856
ISBN-13: 978-0824700850
Product Dimensions: 2.4 x 1.6 x 0.2 cm
Shipping Weight: 939 g

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Product Description

An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors.
Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors

furnishes a historical overview of genetic therapy

highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors

offers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trials

discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications

illustrates for new practitioners how each stage of genetic therapy is developed

details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis

includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy

and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.

Book Info

Thomas Jefferson Univ., Philadelphia, PA. Presents illustrative examples of disease in which genebased interventions are plausible, as well as case studies of current research using both synthetic oligonucleotides and biological vectors. For pharmacologists, biochemists, pathologists, and medical and graduate students. DNLM: Gene Therapy.

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First Sentence
At first glance, the biology of life appears to offer a complexity beyond comprehension. Read the first page

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