I used to be a big Van Damme fan. Timecop, Hard Target and Lionheart are still among my favorite action movies. However, recent Van Damme's movies are rather weak. It is my personal opinion that without a interesting original script and quality professional actors portraying the "bad guys" Van Damme's movies aren't' worth the time nor money.
Brief comments about this movie - very lame story, much weaker than Segal's Under Siege 2 Dark Territory. Some sickening pictures portraying Small Pox outbreak. Supporting cast, excluding Tomas Arana, Laura Harring, range from weak to complete amateurs. Also, special effects are very weak.
On the positive, if you love Van Damme, you will see him doing his usual stuff in the movie. Also, his son makes a theatrical debut with some nice martial art moves.
Overall, I would rather watch again one of my favorite Van Damme movies than this one.