I've been a big comics fan for a while and I would rank Damian up there with some of the best. It's kind of ridiculous to try to make comparisons, but if I had to, I'd compare Willcox to maybe Crumb without the "bordering on mental illness" part -- mildly squemish humor with a heart of gold. Or, put more directly, awesome potty humor! My personal favorites are the characters Kernel Corn and Black-eyed Pea -- a piece of corn and a pea living life in and out of various animal and human intestinal tracts. Damian is just a plain good storyteller - his personal-stories-as-comics are endearing and funny. The mostly one-frame episodes with no captions of Skully (the grim reaper who is conflicted with his destiny to make things die versus his desire to be part of the "real" world) are pretty masterful.
Willcox is a pun machine. For me, there is no such thing as a bad pun...and Damian delivers (is that a compliment?).
The artwork is fantastic too. Damian has clearly developed his own style and voice through his linework and character development. The artwork is like the writing -- deceptively carefree. It's easy to overlook how much craft, detail and creativity is layered into these comics.
I would read it multiple times, but my 9 year old son has sequestered it to an undisclosed location, so I'll have to buy another one.
Don't forget to check out ""Well...this is awkward": A collection of comics, paintings and junk by damian willcox.", his second book. It is also awesome!