This book outlines an excellent journey from Istanbul to Cairo, with all the detail and information we expect from Lonely Planet. The only problem emerges if you want to take a different route than the one they've outlined. They make hardly any allowance for this possibility, and this is the book's fatal flaw. Use it as a suggestion book, as a guide; but consider buying a guide to the Middle East instead, and thus providing yourself with much more information on the places between Istanbul and Cairo, places you may want to visit even though they're "off the beaten track." For instance, with more information I chose to go South through Jordan, ferry to Egypt, and then go back North into Israel, ending in Jerusalem. This made sites such as Petra in Jordan and St. Anthony's Monastery in Egypt fit nicely on the itinerary, and for me ending in Jerusalem provided a more fitting climax. No one trip can fit everyone. Whatever your desires, consider a guidebook that presents more options. Make sure you include Istanbul, Ephesus, Damascus, Baalbek, Beirut, Petra, Jerusalem, Cairo. Strongly consider Nazareth, Haifa, Luxor, and Mt. Sinai. Have fun!