Most helpful customer reviews
4.0 out of 5 stars
Battling the Anecdote, Jan 22 2004
This review is from: Limeys: The True Story of One Man's War Against Ignorance, the Establishment and the Deadly Scurvy (Hardcover)
The blurb is that Dr. James Lind discovered the cure and prevention of scurvy in 1747 by conducting the first controlled clinical trial in the annals of medicine. In spite of his heroic efforts, It took about 50 years for this to finally sink into the medical bureaucracy of the British navy, when the scourge was finally vanquished. Well, the truth is a little more complex than that, and contains some pertinent lessons for our own time. The trial involved only 12 men divided into 6 groups, two of whom got two oranges and a lemon while the others got various other remedies of current interest, including dilute sulfuric acid. The fruit receivers got better, and the others did not. This was the only real trial during the several centuries of extended sea voyages, and was not enough evidence to overcome the objections of amateur observers, anecdotal reports, quacks with their own pixie dust to sell, and the opinions of the committees of the connected. Truth be told, the modest Scot did not really push the method for study hard enough, and complicated his message with speculation and caveats. He was unable to harness the commercial motives of the right people to finally triumph in his own lifetime. Even as late as our own Civil War, and in the concentration camps of the Boer War, tens of thousands continued to perish of scurvy. Interestingly, one of the reasons for the failure, traced by the author, is the confusion of the terminology of the day, when "lemon" and "lime" were terms used inconsistently and interchangeably, while their anti-scorbutic powers differed significantly. One can easily sneer at the ignorance of the those times, but be startled to realize that the same sort of problem exists today in the multi-billion dollar controversy over asbestos, in which two sorts of minerals, comprising six distinct minerals with distinct chemical structures are all lumped together under the same term: asbestos. Journalists and dwellers in the bowels of the EPA and OSHA are as indifferent to the distinction and the evidence for a great difference in the dangers inherent in each of them, as any committee of the Admiralty of Lind's day. As far as the inadequacy of Lind's clinical trial, these problems of methodology have hardly gone away. Spend a few hours researching the clinical data on the important problem of second hand cigarette smoke, and tremble before the power of the mass media and the disregard of the uplifters for real scientific data. Harvey has chronicled the complexities of the discovery well, and his tale serves as a cautionary lesson for those interested in how the truth may finally come to prevail, even in our own time of a plethora of shoddy science, bureaucratic safety committees, and dishonest journalism.
Help other customers find the most helpful reviews
Was this review helpful to you? Yes
No
2.0 out of 5 stars
Science Apartheid, Mar 31 2003
This review is from: Limeys: The True Story of One Man's War Against Ignorance, the Establishment and the Deadly Scurvy (Hardcover)
Despite my interests in history as it relates to science (and more specifically to medicine), I found this work to be sorely tedious. Nonetheless, it would have been redeemable had there been useful organization, instead wondering almost aimlessly among events not much better arranged than a high school term paper. The frequency of repetition also taxed my patience heavily. The irony of the epilogue leaving potential credibility for Linus Pauling's work with high-dose vitamin C in same way he criticized other charlatans' benefactors shouldn't be lost on the reader, but it's more likely the difficult delivery will discourage any reader from getting that far who isn't already heavily invested in evidence-based science. This certainly won't be the work that invites the lay public to be interested in science.
Help other customers find the most helpful reviews
Was this review helpful to you? Yes
No
5.0 out of 5 stars
A story of science and obstinance, Mar 22 2003
This review is from: Limeys: The True Story of One Man's War Against Ignorance, the Establishment and the Deadly Scurvy (Hardcover)
David Harvie has written a fascinating book on the history of the dreaded disease scurvy. Only two mammals are vulnerable to scurvy, humans and guinea pigs, because these two creatures cannot produce their own Vitamin C or ascorbic acid. Throughout history, millions of people, especially sailors and soldiers, died horrible deaths by scurvy. Dr. James Lind, who in 1747 conducted what is considered the worldï¿s first clinical trial, established that oranges and lemons cure scurvy. Yet, because of the lack of understanding by people and Lind's inability to push and publicize his discovery enough, sailors, particularly those in the Royal Navy making extended ocean trips, continued to die by the thousands until the early-1790's, when the Admiralty decreed that lemons and their juice be issued to every ship. By 1795, scurvy in the Royal Navy was eliminated, except in cases where supplies of lemon juice ran out. The most amazing part of the story still lay ahead, because scurvy returned in force during the 1800's, and quack cures were still in use until the 1900's! I leave it up to you to read the book to learn why this happened. The book even mentions Dr. Linus Pauling's work with Vitamin C in the late 1900's. All in all, an excellent read. I would give it 4.5 stars if that were possible, because the writing slows down a little in spots. All writers of science history should study the excellent writing of Dava Sobel, the author of Longitude, the superb history of John Harrison and his clocks.
Help other customers find the most helpful reviews
Was this review helpful to you? Yes
No
|
|
Most recent customer reviews
|