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Liquid Chromatography - Mass Spectrometry: An Introduction Paperback – Apr 2 2003


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"...should significantly enhance...understanding of the selected topic..." (THES Textbook Guide, 27 Feb 2004)

From the Back Cover

This series of books provides coverage of all of the majoranalytical techniques and their application in the most importantareas of physical, life and materials science. Each text ispresented in an open learning/distance learning style, in which thelearning objectives are clearly identified. The reader'sunderstanding of the material is constantly evaluated by the use ofself-assessment and discussion questions.

The combination of gas chromatography with mass spectrometry(GC-MS) has been a routine analytical tool for many years, whilethe related hybrid technique of liquid chromatography-massspectrometry (LC-MS) is a rather more recent development. However,with the advent of new interfacing technology, the benefits of thispowerful hybrid analytical method are now currently being realised,as witnessed by the exponential growth in applications of thistechnique in both the chemical and life sciences.

The topics covered in this text include the following:
* The basic principles of liquid chromatography and massspectrometry

* The limitations of the component techniques when used inisolation, and how a combination of the two allows these to beovercome

* Descriptions of the various approaches, including thermospray,electrospray and atmospheric pressure chemical ionization, whichare used to interface the two techniques, along with the advantagesand disadvantages of each system

* Illustrative examples of the applications of LC-MS, including themolecular weight and structure determinations of both biopolymersand low-molecular-compounds, along with the development ofquantitative methods
Key features include:
* The provision of many discussion and self-assessment questionsthroughout the text, thus providing opportunities for testing thereader's understanding of the subject matter

* Presented in the AnTS (open learning/distance learning) style, itis ideal for use as both a self-study guide and as the basis of ataught course

* A comprehensive bibliography, including books, papers/articles injournals and on websites, along with specific references for theindividual chapters, to guide the reader to more specialised textsand original sources
Written with a student audience in mind, this text will provide aninvaluable introduction to this increasingly important analyticaltandem technique.

Inside This Book (Learn More)
First Sentence
interface exists which possesses similar capabilities to those available for GC-MS, i.e. one that will allow mass spectra to be obtained from any compound that elute from an HPLC column, and thus LC-MS has not been guaranteed to provide the required analytical information. In addition, the complexity of the mass spectrometer has meant that the majority of chromatographers have not had direct access to the instrumentation and have had to rely on a service facility to provide results. Read the first page
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Amazon.com: 1 review
3 of 3 people found the following review helpful
A very good book for beginners and students July 19 2005
By T. Zhao - Published on Amazon.com
Format: Paperback
This book is very fundamental. For someone with little knowledge about HPLC-MS, this is the right book for him/her. IF you want to learn LC/MS, start with this book.


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