This series of books provides coverage of all of the majoranalytical techniques and their application in the most importantareas of physical, life and materials science. Each text ispresented in an open learning/distance learning style, in which thelearning objectives are clearly identified. The reader'sunderstanding of the material is constantly evaluated by the use ofself-assessment and discussion questions.
The combination of gas chromatography with mass spectrometry(GC-MS) has been a routine analytical tool for many years, whilethe related hybrid technique of liquid chromatography-massspectrometry (LC-MS) is a rather more recent development. However,with the advent of new interfacing technology, the benefits of thispowerful hybrid analytical method are now currently being realised,as witnessed by the exponential growth in applications of thistechnique in both the chemical and life sciences.
The topics covered in this text include the following:
* The basic principles of liquid chromatography and massspectrometry
* The limitations of the component techniques when used inisolation, and how a combination of the two allows these to beovercome
* Descriptions of the various approaches, including thermospray,electrospray and atmospheric pressure chemical ionization, whichare used to interface the two techniques, along with the advantagesand disadvantages of each system
* Illustrative examples of the applications of LC-MS, including themolecular weight and structure determinations of both biopolymersand low-molecular-compounds, along with the development ofquantitative methods
Key features include:
* The provision of many discussion and self-assessment questionsthroughout the text, thus providing opportunities for testing thereader's understanding of the subject matter
* Presented in the AnTS (open learning/distance learning) style, itis ideal for use as both a self-study guide and as the basis of ataught course
* A comprehensive bibliography, including books, papers/articles injournals and on websites, along with specific references for theindividual chapters, to guide the reader to more specialised textsand original sources
Written with a student audience in mind, this text will provide aninvaluable introduction to this increasingly important analyticaltandem technique.