When three of Simon's classmates disappear and no one seems to notice, Simon thinks he may be going mad. He and a friend soon discover their missing friends—who have been turned to stone. Nearby they meet a girl, Melissa, who has snakes for hair, only the boys' mirrored sunglasses save them from a similar fate. As the parallels to Greek mythology multiply, Simon uncovers the plot of a megalomaniac scientist who has discovered a blend of ancient magic and modern science that alters the DNA of humans and animals, turning them into mythical creatures. It is up to Simon and his pals to save Melissa's island home—and the world—from the schemes of Doctor X. Sirens, nymphs, hydras, cyclops, and a colorful cast of modern mythological creatures are given a quirky contemporary twist in this exciting and entertaining tale.