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Molecular Biology of the Cell 5th Edition HARDCOVER Hardcover – Student Edition, Nov 16 2007

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Product Details

  • Hardcover: 1392 pages
  • Publisher: Garland Science; 5 edition (Nov. 16 2007)
  • Language: English
  • ISBN-10: 0815341059
  • ISBN-13: 978-0815341055
  • Product Dimensions: 27.9 x 22.1 x 4.7 cm
  • Shipping Weight: 3 Kg
  • Average Customer Review: 4.8 out of 5 stars  See all reviews (4 customer reviews)
  • Amazon Bestsellers Rank: #48,373 in Books (See Top 100 in Books)
  • See Complete Table of Contents

Product Description


"Throughout the book, emphasis is placed not just on what 'we know' but also on 'how we know' and 'what remains to be discovered'- important for engaging and enthusing students....A quarter of a century after the first edition revolutionised cell biology textbooks, the new edition is as fresh, comprehensive and above all, as readable as ever....Like its predecessors, this is a superb textbook for advanced undergraduate and postgraduate students."

-British Society for Developmental Biology Newsletter, Summer 2008, Vol. 29, No. 1

"Professors, lecturers, and instructors will find the fifth edition of the book Molecular Biology of the Cell and its accompanying Problems Book to be an excellent choice for guiding their students through the maze of the cell's molecular structures and biochemical processes....With countless colorful illustrations and a large number of photographs and tables, reading the text becomes not only an educational experience, but also a highly enjoyable one for those students who wish to discover the inner workings of the magnificent cellular machine....Educators will also find the DVD-ROM to be a rich electronic resource when compiling their lectures....No less important is the Problems Book, which contains numerous exercises and questions that are an integral part of the learning process, and that teachers, instructors, and students are sure to appreciate."

The Quarterly Review of Biology, September 2008, Volume 83, Number 3


"It has been 25 years since the first edition of Molecular Biology of the Cell (MBoC) was published, which means that roughly half of today's practicing scientists do not remember life without this cell biology `bible'. The other half might recall how the book almost instantly filled a void with refreshingly clear and engaging writing illustrated with extensive diagrams and figures….MBoC has only improved over its several editions, growing with the rapid advances in the field to become an essential resource for students at all levels and a trusted first stop for researchers transitioning into unfamiliar areas of cell biology….An enduring strength of the book is that it remains a comprehensive textbook….In addition to the comprehensive updating of every chapter, another reason to consider acquiring edition five is the improved integration of the print volume with an extensive array of videos and animations in the `Cell Biology Interactive' provided on the accompanying DVD….Another welcome improvement in MBoC5 helps link the textbook to the lab - there are now problems printed at the ends of the first 20 chapters. Whereas some are designed to facilitate information retention, the best problems stimulate thought and challenge the reader to think about experimental approaches for learning new things about cell biology….the MBoC5 package is a fantastic resource and well worth the upgrade."

-Development (Company of Biologists) 135, 3973-3974 (2008)


"[Molecular Biology of the Cell] is a marvelous textbook. Once again, the authors are to be congratulated on a superb achievement. We are amazed at the scope and depth of information provided.”
- Bioscience Education

About the Author

Bruce Alberts received his PhD from Harvard University and is Professor of Biochemistry and Biophysics at the University of California, San Francisco. For 12 years, he served as President of the U.S. National Academy of Sciences (1993-2005).

Alexander Johnson received his PhD from Harvard University and is Professor of Microbiology and Immunology and Director of the Biochemistry, Cell Biology, Genetics, and Developmental Biology Graduate Program at the University of California, San Francisco.

Julian Lewis received his DPhil from the University of Oxford and is a Principal Scientist at the London Research Institute of Cancer Research UK.

Martin Raff received his MD from McGill University and is at the Medical Research Council Laboratory for Molecular Cell Biology and the Biology Department at University College London.

Keith Roberts received his PhD from the University of Cambridge and is Emeritus Fellow at the John Innes Centre, Norwich.

Peter Walter received his PhD from The Rockefeller University in New York and is Professor and Chairman of the Department of Biochemistry and Biophysics at the University of California, San Francisco, and an Investigator of the Howard Hughes Medical Institute.

Inside This Book

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Customer Reviews

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5 of 5 people found the following review helpful By Dano on Dec 3 2007
Format: Hardcover
I received the hardcover edition friday the 30th of November 2007 in the mail, and then discovered what the Reference edition of this book is.

This hardcover edition, and hence the softcover, is a STUDENT EDITION. As a consequence, the last 5 chapters are included on a DVD-ROM rather than printed within the book (accounting for the difference of about 300 pages).

You should consider this before buying this textbook. If you want then entire book in print, wait for the REFERENCE EDITION ISBN: 0815341113.

That being said, this new edition is well worth getting.
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1 of 2 people found the following review helpful By DarkJedi on Oct. 11 2010
Format: Paperback
This is a paperback book. I got the paper back because I don't want to carry the book in my bag as it is large and heavy. If you're going to carry the book around I recommend the hard cover. The book is also not a complete edition and a few of the last chapters are on a DVD which was included. I am using this book in a Principles of Molecular Biology course at the University of Waterloo and it was a recommended text by my professor. I like this book, it is filled with images and is very descriptive. Very detailed and goes very deep into the topics.
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1 of 2 people found the following review helpful By Divine Comedy on Aug. 7 2009
Format: Hardcover
The quality is really good. It looks brand new, as described in the seller's item description. Very, very satisfied.
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0 of 2 people found the following review helpful By Angela on Feb. 11 2012
Format: Paperback
Arrived very quickly and in perfect condition, as described in the product information. It did not ship from Nova Scotia as stated, though.
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Most Helpful Customer Reviews on Amazon.com (beta)

Amazon.com: 313 reviews
212 of 217 people found the following review helpful
CD contents are worth hundreds of dollars June 1 2002
By Mel Beckman - Published on Amazon.com
Format: Hardcover Verified Purchase
I'm an amateur biologist, and a professional computer software engineer and product reviewer. A keen interest in the mechanics of genetic expression has drawn me to the beautiful details of cellular mechanics. While this book is everything the other reviewers say (and are qualified to say) it is, let me weigh in on the accompanying CD, which is an area in which I can claim some expertise.
The vast majority of CDs bundled with textbooks are afterthoughts -- either an electronic copy of the text, or some lightly related adjunct materials, usually pulled from the public domain. MBotC is different. The CD is nothing short of breathtaking. A technical tour de force, this CD runs on both Mac and Windows, which is no mean feat. It leverages time-tested technologies such as Netscape, Java, and Quicktime to produce stunningly vivid presentations. It performs well, and is rock-solid stable.

Beyond flawless delivery, the content itself is brilliantly executed. This is largely original content developed for this book, and tied directly into the text chapter by chapter. You get narrated animations that show dozens of cellular processes in a way that catalyzes learning. Videos capture live microscopy showing ATP synthase rotors spinning, microtubules self-assembling, actin crawling, and mitosis mitoting. An image magnifier lets you browse photomicrographs in detail.
Most astounding of all is the seamless incorporation of a molecular viewer, the Chime Java browser plugin, which directly reads and interprets Protein Data Base (PDB) files and displays the models in interactive 3D. The CD includes hundreds of PDB models, including a wonderful reference library of amino acids, nucleotimes, lipids, and sugars.
The CD alone is worth hundreds of dollars, just in the labor expended to assemble material from labs around the world and organize it to fit the chapters of the text. I've used numerous of CDs promising to teach molecular biology, and nothing else comes remotely close to the quality and depth of this volume.
That you can buy the CD -- with a ten-pound book attached -- for [the price] is simply a miracle. It's a no-brainer for anybody remotely interested in cell biology. If you're one of them, you must buy this!
111 of 115 people found the following review helpful
One of my absolute favorite textbooks... July 1 2000
By K. L Sadler - Published on Amazon.com
Format: Hardcover
In graduate school for Neuroscience I had to take a class on molecular biology and biochemistry which was required of all med students whether Ph.D. or M.D. or both. We had five different teachers in the class, three of whom were foreign. Since I was the first Deaf person to take Neuroscience there, they weren't prepared for me...and I ended up taking the class without interpreters! I had to lipread the teachers. If it hadn't been for this particular textbook, I would never had made it through! I am not kidding anyone by saying this. YOu can take a class with just this textbook for information and still pass with flying colors. That is how well this text is written. For once, the book was written with the student in mind, not the peers of the authors. It was written to teach the same information that the authors had in such a way as to make it understandable. Not only did I use this text in this class but in most of my classes at med school. When I started working on HIV encephalitis in my chosen lab for two years, I was not surprised to find this book on the shelves...and we all referred to it constantly. I applaud the authors for a job well done, and if I ever write a textbook, this will be the one I use to follow as an appropriate way to write curriculum. The amount of pictures and graphs were especially great for teaching Deaf students and I intend to use it for such. Karen Sadler, Science Education, University of Pittsburgh
75 of 76 people found the following review helpful
Great, but Last 5 Chapters are Electronic Jan. 12 2008
By A. LUJAN - Published on Amazon.com
Format: Hardcover
GREAT book, but the only problem is that the last 5 chapters are in PDF format on an attached CD rather than in print (they did this to make the book more portable). If you want the full print version, buy the Reference edition.
70 of 71 people found the following review helpful
Comprehensible by Non-Specialist Sept. 16 2009
By Bob Carpenter - Published on Amazon.com
Format: Hardcover Verified Purchase
[Reviewing 5th Edition, Chapters 1-7] I'm a Ph.D. computer scientist working on an NIH grant in text mining biomedical literature, so I thought I should bone up on the underlying science. The first seven chapters of this book are just what I needed. The first overview chapter is an excellent standalone introduction to the cell and genomics/proteomics and their ilk. After a two-chapter very comprehensible introduction to biochemistry (strong emphasis on thermodynamics/energy and bonding/structure) and protein structures, the next chapters lay out the entire process from DNA to protein, including expression control.

It's slow reading (it takes me an hour or more to read 10 pages), but very clearly written, and very thorough. The diagrams and accompanying text are amazingly clear and helpful. (There are also animations, but I've never looked at the DVD.) The diagrams and their long captions are often supplementary in that they add details that are not in the body of the text.

I had read the same sections of the 4th Edition a few years ago. The 5th edition adds substantial new material starting with the chapter on proteins. Ironically, the 5th edition is more speculative, because the more we find out about gene expression, the further away full understanding seems to be. The book does a nice job of balancing what's known fairly certainly with speculative guesses about things like chromatin structure.

This time, I think I'll keep going. The sections of the rest of the book I've browsed when they've been cross-referenced are also excellent.
74 of 77 people found the following review helpful
They keep getting better Aug. 24 2003
By Dr. Lee D. Carlson - Published on Amazon.com
Format: Hardcover Verified Purchase
In the past few years quite a few books on molecular biology and genetics have appeared, and all of these have been exceptionally well-written. Most have been updates of previous editions, and if compared with these, the most recent editions have displayed an enthusiasm and excitement that dwarfs their earlier editions. This book, now in its fourth edition, is an example of one of these, and I believe the reason for their increasing quality is the excitement that biologists are now feeling. This is due no doubt to the incredible strides that have been taken in biology in the last few years. Biologists are with complete justification very excited that they understand in greater detail what life is all about, and are looking forward to an even deeper understanding in the decades ahead.
As a non-biologist but one deeply embedded in bioinformatics and certain areas of computational biology, this book served my need to understand in greater detail the underlying biology behind these fields. It is a beautiful book, both from an aesthetic viewpoint and because of its content. The book reads more like a story than a textbook, but the information gain when reading it is considerable, with less entropy than what might be expected from such a deep subject with myriads of terms that must be understood before moving on to others. The author's approach to the book is well-organized, with many accompanying diagrams that illustrate the complicated processes and structures that can occur in the molecular realm. In addition, helpful summaries are put at several places in the book. There are no exercises in this book but there is a workbook that one can purchase separately.
Space prohibits a detailed review of such a large book, but some of the more interesting discussions in the book include: 1. The paragraph on the role of sex in bringing about horizontal genetic exchanges within a species. The thinking is that the genomes of modern eubacteria, archaea, and eucaryotes originated in three different "anthologies" of genes that survived from an ancestral pool in which genes were frequently exchanged. This hypothesis is tempting, argue the authors, since it would explain the fact that eucaryotes are similar to archaea in terms of genetic "information-handling" but more similar to eubacteria from a metabolic standpoint. Horizontal gene transfer has become a very important topic of late, due in part to the uproar on bioengineered foods. 2. The suggestion that eucaryotic cells originated as predators, pointing to the presence of mitochondria as one piece of evidence. 3. The entire chapter on proteins, but especially the discussion on protein folding, allosteric enzymes and allosteric transitions. The discussion on protein folding is qualitative but the authors give interesting insights on this topic. In answering the question as to why only a few of the 20^300 different polypeptide chains will be useful to a living organism, they point to natural selection, and the resulting conformations being stable due to its fine tuning. The extreme sensitivity of protein function to small changes in their structure has recently fueled speculation by religionists as being evidence of "intelligent design", but such speculations, even if true, will not improve the understanding of proteins, and can therefore be safely ignored from a scientific viewpoint. The authors do devote a short paragraph to the discussion of computational methods in the protein folding problem, and also discuss briefly the experimental difficulties in determining the conformations of proteins. They also give some of the mathematical details of steady state enzyme kinetics. 4. The discussion on the need for low mutation rates in order to have life. 5. The section on abnormally folded proteins and their relation to diseases, such as prion diseases. Prions have been a contentious issue of late, due to the issues with "mad cow disease" in Great Britain. 6. The section on the "RNA world" and the origins of life. The authors discuss the need in early cells for molecules to perform reactions that lead to the production of more molecules like themselves. From the standpoint of modern cells, polypeptides, they point out, can serve to be catalysts, but they emphasize that there is no known way in which this type of molecule can copy itself by the specification of another of precisely the same sequence. The talk about one theory, the "pre-RNA" world, as justification for the need for simpler compounds to act as template and catalyst for the synthesis of complementary RNA. 7. The section on heterodimerization and its use in "combinatorial control", the latter being a process in which combinations of different proteins control a cellular process. Although not discussed in this book, the mathematical modeling of combinatorial control and its role in signal transduction systems has taken on more importance in recent years. 8. The section on how genetic switches work and the role of operons thereof. 9. The phenomenon of "transcriptional synergy" in gene activator proteins. Here the transcription rate is higher when several activator proteins are working together than when any of the activators are working alone. 10. The discussion on how circadian clocks can be created using feedback loops in gene regulation. The authors describe an interesting experiment that produced a simple gene clock using techniques from genetic engineering. 11. The section discussing RNA interference, a topic that has taken on enormous importance lately, since using it allows researchers the ability to turn off the expression of individual cellular genes. Indeed pharmaceutical bioinformatics and the role of "in silico" molecular target identification makes use of the ability to "tune" phenotypes by using RNA interference for laboratory validation of the bioinformatic algorithms.