I'm not a Lynch's fan because Mulholland Drive is the first and only film I've ever watched from him, so I hope this can be considered an impartial comment. This movie is PURE ART! It moves your deepest emotions completely, including fear, jealousy, sadnes, intrigue, hate and (a little) love with great picture and awsome dialogs, music is sometimes an important element too. However in my experience, the process of appreciating this movie was slow. The first time I watched Mulholland Drive, in the movie theater, it ended and all I had in my mind was a big question mark. What was this all about??!! However I did not dislike it and months later I gave it a second chance, on DVD, and this time I was shocked. This big question mark inside my head became many small question marks and, after watching it several times, many of them are still there. But that is one of the things that makes Mulholland Drive so GREAT, it's complexity and the enigmas that remain open and may be answered in so many ways. It is also full of symbolic elements that would have no sense if you watch it like any traditional movie, their meanings, however, are not cleared during the movie, you'll have to discover them yourself and it's not easy to do it. That's why I'd say this one is for intelligent watchers only. I'll not describe the story because you'll find it in other comments, but I think this is for people looking for an emotional-artistic experience, and not for people who want an "interesting story". If you like the kind of movies that stays away from conventional Hollywood trash; if you enjoyed, for example, Memento or PI, then this is the next one you MUST watch.