This film may not be for everyone, but it is for everyone that 'gets it'. Tim Burton was not out to make one of those tremendously stupid films involving a really dumb guy and the antics that he gets into wherever he goes, although it appears to be something like that from far away. What he and Reubens created was actually the crazy adventures of a somewhat wet-behind-the-ears and sensitive manchild looking for his stolen bike across the American southwest. The humour doesn't not come from all the ridiculous things that happen to him, rather it comes from his reaction to the (somewhat) normal, if unlikely, situations he gets into. This is the genius of Paul Reubens, Pee-Wee has very simple needs and wants, but his reactions to his situations are always cheeky (and a little dark).
Hence, if you can attach yourself to this character early on in the film, you will be rolling on the floor with laughter the entire length of it. Pee-Wee has this unrelenting way of making you feel like you should be as happy as him. And that is a good film in my book, one that makes you want to be a more positive person.
PS He will make you think that your bike is a two-bit piece of crap compared to his. I really want that bike.