Popoton is about 4 women (3 sisters and a maid) with weird magical powers who travel around to different areas looking for Popotons (tonpopo's actually, which is the Japanese word for Dandelions). There is definitely something odd about the 4; they seem to have magical powers (for instance, Ai can talk to flowers), and what happens at the end of every episode is the house they live in takes flight, pretty much in the same manner as the dandelion spores, as they travel on their way to the next location.
Each episode is a self contained story which usually involves them helping someone who has problems. The first episode is a boy who is trying to help a girl in his class prove ghosts are real. The second is actually assisting one of the women in the house, Mai, as she hates the feeling she gets when she moves from area to area and loses the friends she's made along the way. The third involves a little girl sick in the hospital who can't go outside or leave the hospital due to her illness. The fourth episode is a little girl who is alone (I can't say anymore as to avoid spoilers).
Animation is high quality stuff (for a TV series anyway). Japanese voice acting is spot on and the show is just a lot of fun to watch.
Mii is played by Momoi Haruko, or... better known as Komugi from Nurse Witch Komugi and The Soul Taker. The character she plays resembles Komugi, actually. They even give her an episode where she Cosplays as a magical girl.
There are also plenty of bare breasts and other various fan service related bits to be found.
What surprises me is the 16 and up rating. I guess it's for the bare breasts, and the bare breasts aren't REALLY shown in a lewd/perverted manner, at least not in my opinion. Other than that, this show is definitely aimed at a broad range of folks, I mean, I think I'd be hard pressed to find a young kid who couldn't enjoy the themes in the show. It's a light hearted show with warm and caring characters... with some bare breasts thrown at you from time to time.
So Popoton gets a high recommendation from me. However, if you don't like cute shows, stay way.