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Principles of Neural Science, 5th Edition [Hardcover]

Eric Kandel , James Schwartz , Thomas Jessell , Steven Siegelbaum , A.J. Hudspeth
4.0 out of 5 stars  See all reviews (3 customer reviews)
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Book Description

Sept. 27 2012 0071390111 978-0071390118 5

Now updated: the definitive neuroscience resource—from Eric R. Kandel, MD (winner of the Nobel Prize in 2000); James H. Schwartz, MD, PhD; Thomas M. Jessell, PhD; Steven A. Siegelbaum, PhD; and A. J. Hudspeth, PhD

900 full-color illustrations

Deciphering the link between the human brain and behavior has always been one of the most intriguing—and often challenging—aspects of scientific endeavor. The sequencing of the human genome, and advances in molecular biology, have illuminated the pathogenesis of many neurological diseases and have propelled our knowledge of how the brain controls behavior.

To grasp the wider implications of these developments and gain a fundamental understanding of this dynamic, fast-moving field, Principles of Neuroscience stands alone as the most authoritative and indispensible resource of its kind.

In this classic text, prominent researchers in the field expertly survey the entire spectrum of neural science, giving an up-to-date, unparalleled view of the discipline for anyone who studies brain and mind. Here, in one remarkable volume, is the current state of neural science knowledge—ranging from molecules and cells, to anatomic structures and systems, to the senses and cognitive functions—all supported by more than 900 precise, full-color illustrations. In addition to clarifying complex topics, the book also benefits from a cohesive organization, beginning with an insightful overview of the interrelationships between the brain, nervous system, genes, and behavior. Principles of Neural Science then proceeds with an in-depth examination of the molecular and cellular biology of nerve cells, synaptic transmission, and the neural basis of cognition. The remaining sections illuminate how cells, molecules, and systems give us sight, hearing, touch, movement, thought, learning, memories, and emotions.

The new fifth edition of Principles of Neural Science is thoroughly updated to reflect the tremendous amount of research, and the very latest clinical perspectives, that have significantly transformed the field within the last decade.

Ultimately, Principles of Neural Science affirms that all behavior is an expression of neural activity, and that the future of clinical neurology and psychiatry hinges on the progress of neural science. Far exceeding the scope and scholarship of similar texts, this unmatched guide offers a commanding, scientifically rigorous perspective on the molecular mechanisms of neural function and disease—one that you’ll continually rely on to advance your comprehension of brain, mind, and behavior.

FEATURES

  • The cornerstone reference in the field of neuroscience that explains how the nerves, brain, and mind function
  • Clear emphasis on how behavior can be examined through the electrical activity of both individual neurons and systems of nerve cells
  • Current focus on molecular biology as a tool for probing the pathogenesis of many neurological diseases, including muscular dystrophy, Huntington disease, and certain forms of Alzheimer’s disease
  • More than 900 engaging full-color illustrations—including line drawings, radiographs, micrographs, and medical photographs clarify often-complex neuroscience concepts
  • Outstanding section on the development and emergence of behavior, including important coverage of brain damage repair, the sexual differentiation of the nervous system, and the aging brain
  • NEW! More detailed discussions of cognitive and behavioral functions, and an expanded review of cognitive processes
  • NEW! A focus on the increasing importance of computational neural science, which enhances our ability to record the brain’s electrical activity and study cognitive processes more directly
  • NEW! Chapter-opening Key Concepts provide a convenient, study-enhancing introduction to the material covered in each chapter
  • Selected Readings and full reference citations at the close of each chapter facilitate further study and research
  • Helpful appendices highlight basic circuit theory; the neurological examination of the patient; circulation of the brain; the blood-brain barrier, choroid plexus, and cerebrospinal fluid; neural networks; and theoretical approaches to neuroscience/ul>

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Principles of Neural Science, 5th Edition + The Age of Insight: The Quest to Understand the Unconscious in Art, Mind, and Brain, from Vienna 1900 to the Present + In Search Of Memory
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Most helpful customer reviews
2.0 out of 5 stars A mediocre update March 22 2013
Format:Hardcover
Some of the content is outdated and poorly written. This long-delayed new edition needs to be edited for grammar and clarity. It's unfortunate that this mediocre text book is the standard for the field.
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5.0 out of 5 stars Great learning tool Feb. 12 2013
Format:Hardcover|Verified Purchase
This text is a fantastic adjuvant to any neuroscience course. It is a very easy read with a logical flow with figures that significantly solidify learning of concepts.
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5.0 out of 5 stars This is what I want. Jan. 23 2013
By Joanna
Format:Hardcover|Verified Purchase
This is what I want. With so many colorful pictures, it is more easy to understand and learn, especially for beginners like me.
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Most Helpful Customer Reviews on Amazon.com (beta)
Amazon.com: 4.7 out of 5 stars  45 reviews
56 of 58 people found the following review helpful
5.0 out of 5 stars THE reference textbook for grad studies Dec 11 2012
By Sylvain Pronovost - Published on Amazon.com
Format:Hardcover
I purchased the 4th edition of Principles of Neural Science back in 2001, when I was studying at McGill in cognitive science and neuroscience. This was the most useful introduction on the subject matter of neuroscience, and its amazing breadth and depth was sufficient to cover all the basics and find references for further readings on specific topics.

I used it extensively when I started my PhD in cognitive science at Carleton University and had a challenging, full-year course in behavioral neuroscience. The fourth edition has aged well as an introduction, but the neuroscience community was longing for an update in a field which is less forgiving about years-old sources. It is sad that it took 12 years (!) for an update, but what an update it is!

The 5th edition clocks at 350 additional pages approximately, and while the original material has been preserved where it is required, it *has been updated*. Sections on cognitive processes and behavioral features have been added, more details on aging and neuropathologies/lesions, and of course, the artwork is wonderful. It is slightly more pedagogically-oriented, which was not even a shortcoming in the previous edition. Awesome updates on the reference material to cover the work between 2000 and 2008-ish (I know, it's not up to 2012, but that's how editing and publishing works, viz., slowly).

The icing on the cake is the new computational neuroscience stuff, which is to me invaluable, considering that I study cognitive science in general, and computational cognitive modeling in particular. Add appendices on the theory of neural wiring/engineering and computational modelling, and this is a good A+.

I might be biased, since I wanted this book to be awesome, but hey, they did it again.

Only gripe: at 1760 pages in hardcover format, it's heavy as hell and anyone under 125 pounds will likely hurt their back though, so carry this book in a cart or something ;-)

I wish there was an eBook format like epub or even pdf at an affordable price, at least for purchasers of the hardcover version! I would *love* to have this book on my iPad.
21 of 22 people found the following review helpful
3.0 out of 5 stars Used for formal neuroscience education Jan. 9 2014
By Allunknowing - Published on Amazon.com
Format:Hardcover
This book covers fundamental aspects of neuroscience. Its purpose is to be conservative, so it doesn't delve into controversial, rare, or truly cutting edge research. Near every student and professor of neuroscience has this or its 4th edition.

Basically, an undergraduate degree in neuroscience consists of taking fundamental classes in chemistry, biology, physics, and psychology, as well as reading a big chunk of this book (the principles of neural science) and getting some neuroscience related lab experience (if the program is good). But, the neuroscience part of the neuroscience degree mostly has to do with reading lots of this huge book. A PhD in neuroscience consists of reading a million journal articles, conducting research, and often consulting the principles of neural science (mostly during the first year or two...I didn't, but most do). The book still remains on the desk or in the bookcase of even the most veteran researchers and professors , for there is no better way, in theory, to brush up on or become familiar with a traditional area of neuroscience quickly than starting with this book. Say I'm a new assistant professor and am asked to give a lecture on a neuroscience area far outside my specialty. First, I might quickly scan the topic in the principles of neural science; second, I might go to pubmed and read an up-to-date review on the topic; finally, I might focus in on a couple specific research papers in the area that most attract my curiosity. And bam. In three or four hours I've gone from not knowing a single thing about the topic to being able to give an hour long lecture or lead a discussion on it.

My purpose in writing that rambly note was to illustrate the potential relevance of the 'principles of neural science' to professional neuroscientists at every level. However, the series has some flaws, which mostly mirror some of the difficulties facing the field at large. It is bogged down with tons of excessive detail but is lacking in big picture concepts or recognized patterns to make sense of all the info. Don't get me wrong, I like all the details and know how many of them can directly connect up with biomedical applications. In the end though, readers should understand that this book currently reflects the vision that Eric Kandel has of neuroscience, which is quite radically reductionistic. Some like that; some don't.

Bottom Line:
I think the latest edition of this book makes an excellent cornerstone text for covering areas of molecular biology and cell physiology related to neuroscience for undergraduates. If you are pursuing an interest in neuroscience on your own because of your own curiosity, independent of the educational system, then I would not recommend this text (unless you have read quite a few other text books and want more specific info on neuroscience but can't get access to journal articles). If you are curious about a specific area of neuroscience, then the journals are where you need to be. If you have a more general interest in neuroscience, then I suggest reading something like 'Neuroscience: Exploring the Brain,' which gives all the important fundamental information and is accurate without being bogged down with superfluous detail. Now that I think of it, I personally haven't opened my 'principles of neural science' book since I was an undergrad. It is sort of in this netherworld between having the good overview info of a well thoughtout textbook and the factual specificity found in a journal article. Overall, it gets 3 stars, which amazon says means it's OK, which is exactly what I'd tell someone in person who asked about it....."meh....it's OK." But that doesn't change the fact I'd be talking about the book unequivocally accepted to be the bible of neuroscience.

-Hope this was helpful

P.S. I know many of you will disagree with my rating, thinking it should be higher. I'd ask that you don't mark this review as unhelpful simply because you disagree. This book is/was likely mandatory reading for you anyways, as it was for me (although I felt compelled on my own to get this new edition) so reviews don't have an influence on whether or not you purchase or read it. My review is aimed at those who aren't required to buy this book. To reiterate my justification for a review of "OK" rather than "good" or "great": the book is too detailed. It is bogged down in a way that will keep many non-experts from being able to enjoy the book and integrate all the information. At the same time, the book isn't detailed enough to be really useful to an expert in any single area. There's a quote from someone wiser than me that would fit well here, but I can't recall the specifics...only the gist, which is that the difficult part isn't figuring out what you need to include, but what you can leave out. This book would have benefited from editor's who understood and applied the meaning of this quote.
11 of 11 people found the following review helpful
5.0 out of 5 stars Masterpiece for Neural Science studies May 24 2013
By Serge Marinkovic MD - Published on Amazon.com
Format:Hardcover|Verified Purchase
I am a urologist specializing in neurologically impaired patients so I read Kandels newest edition once they become available. This edition is superb with colorful and easily understood illustrations, diagrams and radiology studies including PET scans. The print is very legible and the spacing is perfect. It took a month to read the 1700 pages but its the best book i have read these last 10 years with Bruce Alberts Molecular Biology of the Cell whose 6th edition should be out later this year. I really found the molecular biology and anatomy chapter the perfect reintroduction for me. It provided me with the perfect detail and understanding for a paper I am writing on Strokes and their Effect on the Bladder. The disease specific Chapters on Stroke, Parkinsons, Multiple Sclerosis each are well detailed but with excellent explanations of the principles necessary for the clinician to get a strong hold on this relevant material. These chapters should be standard reading for all medical students and residents. The radiological studies chosen to illustrate these disease entities are the best i have seen and explain what is important to know and understand for each type of stroke, progressive MS or non progressive MS. I purchased it early after its release new for 70 dollars so with its success it will soon be a classic at 100 plus dollars and will still be worth every penny. I will now use this to teach my students the fundamentals of a neurological exam and to emphasis the commonly seen neurological disease seen by urologists. Thank you Dr Kandel for a book well worth the 7 year wait.
10 of 11 people found the following review helpful
4.0 out of 5 stars 5th Edition, Still A Classic July 29 2013
By Andrew Mckenzie - Published on Amazon.com
Format:Hardcover|Verified Purchase
After its release was pushed back many times, the 5th edition finally came out within the past year, and I have been reading it on my laptop's Kindle app throughout my first year of core PhD courses and in preparing for my qualifying exam. I had read some of the 4th edition during undergrad, as well.

In general my feelings towards the book are warm, and I do expect that if you read the textbook, dear reader of this review, you will learn a lot from it.

Positives

1) Does a good job of not trying to be Alberts' *Molecular Biology of the Cell*. The sections on cell biology, the central dogma, and non-neuroscience-related signaling pathways are refreshingly bare-boned. Seek resources elsewhere if you want to go ham on transcription, translation, and the MAPKKK-MAPKK-MAPK cascade.

2) Perception, sensation, and movement were not the reasons that I first became interested in neuroscience, and, generalizing from my one example as is de rigueur in book reviews, I think that is true of most students. And while this might be just Stockholm syndrome, I'm actually quite happy that there is so much detail and care put into these sections which make up around 1/3rd of the text. These fields are way more tractable to study than the sexy emotion, learning, and personal identity, yet the most of the principles that have been discovered there are likely to generalize.

As an example of this, consider the work of Charles Sherrington, who among other accomplishments won the 1932 Nobel for explaining spinal reflexes as a balance of excitation and inhibition. And now that we have some fancy techniques like conditional genetic KOs and optogenetics, we know that a variety of other phenomena, from critical periods to anxiety, are also regulated via a very similar balance of excitation and inhibition.

3) Most chapters do an excellent job of motivating their material. For example, they emphasize themes from the history of how people have thought about the brain, e.g. James and Freud. There are also a few references to art and literature, such as Gabriel Garcia-Marquez, that are really money.

4) Most fundamentally, this is the eminent textbook on how your mind works and how you are able to understand the words that you are currently reading. And there are some chapters, especially the last three (65 - 67), that really delve into this. What's there not to love?

Negatives

1) In general neuroscience tries very hard to distinguish itself from psychology and this makes good sense in terms of specialization. But the field is still operating in the wake of Karl Lashley, a famous experimentalist who in the 1930s concluded that brain regions had "equipotentiality" for learning mazes not because his lesions were flawed but because his tasks were not specific enough. Designing behavioral tasks is not trivial. Yet, you will not read much about the principles behind how to do so, and nothing about the matching law or Rescorla-Wagner. (My bias: I did some research in learning and behavior in undergrad.)

2) For one of our classes we read an older (3rd edition) version of Chapter 13 on Neurotransmitters. There were way more equations explaining different models of neurotransmitter vesicle release patterns, e.g. explaining the use of the Poisson distribution as an approximation for the binomial. It doesn't make sense that the text has become less quantitative at the same time that math has become easier to use to explain phenomena, as a result of advances in systems biology and just programming generally.

3) Why does searching for "optogenetics" yield me zero results?

4) I prefer my pedagogical material to be structured in the format of *example 1*, *example 2*, (*optional example 3*), and *inducted principle*. The examples only matter insofar as they motivate the principles. Kandel's textbook strays slightly too far from this, I think. In particular, the text tends to enshrine the examples, such CREB, CamKII, PKA, and the ilk, as worthy of our worship in and of themselves. This sets the trend for how neuroscience courses should be taught and for that reason it is a bit troubling.
10 of 11 people found the following review helpful
5.0 out of 5 stars An excellent update Dec 4 2012
By Ronald Potter-Efron - Published on Amazon.com
Format:Hardcover|Verified Purchase
Having only read the 4th edition last year I was eager to see the newly updated version. It is bigger and better, with excellent photographs and charts and far greater detail than in the past. It's very readable as well, partly because there is enough repetition of these difficult concepts to make them understandable.
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