I adore this show--it's a guilty pleasure! I think I know maybe I should be more critical, given some very valid points about its plot and details. But I just disregard it all--it's suspension of belief, and it's so entertaining, the little slip ups or unrealistic bits just don't register.
The cast is stellar. Of them all, star Wentworth Miller is maybe lacking a little bit of range, but his character is so likeable, you can't help but appreciate his presence and cheer for him. The other characters are very dynamic, and luckily, aren't the scum of the earth type some may associate with a prison setting, which is refreshing, and I would think somewhat truthful.
Yes, prison's much nastier than Prison Break tries to show (everyone always refers to Oz as the prison drama with a real taste of what it's like on the inside), but really, this was never meant to be an 'R' or 18A show.
While it's completely different from Lost, it has some similarities. Where Lost is brilliant and infused with all this mystery and mysticism that is still discussed and debated over (when parts of it may have been introduced very early in the series), Prison Break is relatively "mundane"--not boring, but it's a study of what people can accomplish by *doing* things, rather than Lost's periodic exploration of faith and fate. There is still of course mystery in this show, with the goal being an intensely elaborate plan to escape prison, only the mysteries are more like problems; problems presented to viewers every episode that you worry at, with the answer revealed (always quite cleverly) at the end, along with a KILLER cliffhanger!
With hair-raising suspense, noteworthy acting, wonderful characters, and a breakneck pace, it's hard not to be seduced by the show.