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Dr. Richard Clayton (Ron Livingston) has it all: A loving fianc‚e, Ellen (Neve Campbell), two wonderful, supportive parents (Edward Hermann and Christine Baranski), a successful career as a psychiatrist and a self-help book on anger management climbing the best seller list. Everything in his life is right on course until his jealous brother (Bob Odenkirk) tells Richard he was adopted. A private investigator locates his birth parents, Frank and Agnes Manure (Danny DeVito and Kathy Bates): a couple of crude, unrefined and offensive Carnys. Frank and Agnes proceed to make Richard's life miserable, from nearly destroying his relationship with his adoptive parents and close friends, to sabotaging his career during a live television taping promoting his new book, to nearly ruining his approaching marriage. Although Richard's life appears to be in shambles, he learns that he may have something positive to learn from Agnes and Frank Manure after all.