She is the author of twenty-nine previous suspense novels. Her first book, a biographical novel about George Washington, was re-issued with the title, Mount Vernon Love Story, in June 2002. Her memoir, Kitchen Privileges, was published by Simon & Schuster in November 2002. Her first children's book, Ghost Ship, illustrated by Wendell Minor, was published in April 2007 as a Paula Wiseman Book/Simon & Schuster Books for Young Readers.
She is co-author, with her daughter Carol Higgins Clark, of five holiday suspense novels Deck the Halls (2000), He Sees You When You're Sleeping (2001), The Christmas Thief (2004), Santa Cruise (2006), and Dashing through the Snow (2008).
Mary Higgins Clark was chosen by Mystery Writers of America as Grand Master of the 2000 Edgar Awards. An annual Mary Higgins Clark Award sponsored by Simon & Schuster, to be given to authors of suspense fiction writing in the Mary Higgins Clark tradition, was launched by Mystery Writers of America during Edgars week in April 2001. She was the 1987 president of Mystery Writers of America and, for many years, served on their Board of Directors. In May 1988, she was Chairman of the International Crime Congress.