If you allow yourself to be contaminated by the gallows humour at work in the Thackery T. Lambshead Disease Guide, I'm quite sure you'll find it a treasured addition to your library. The writing is often quirky and inventive, and while not all of it is great, the work of such talented people as Stepan Chapman (who writes the best stuff in the Guide), Michael Cisco, Jeff Ford, Shelley Jackson, Michael Moorcock, Alan Moore and Jeffrey Thomas, easily makes up for the few uneven spots the book has.
The Guide is also beautifully produced, with superb design and illustrations by John Coulthart that reflect his obsessive attention to detail. Michael Moorcock's disease entry, set in flawless mock-Victorian style, is perhaps the most striking example.
The Lambshead Disease Guide is a strange and original book that overflows with talent. It's perhaps not for the squeamish, but the humour, though dark, is brave and commendable for it dares to laugh (or at least chuckle) in the face of our own mortality and some of our greatest fears. Can't recommend it enough, definitely one of the best books of 2003.