At the birth of two babies, one white and one black, a mysterious and powerful Conjure Woman (Maya Angelou) prophesizes, "You're going to make a difference and start change." And indeed, they do. Luke Winter (Cody Newton) and Joshua "Sonny" Monroe (Duane McLaughlin) grow up as best friends in a rural Georgia town in the 1940's. On one of their youthful adventures they uncover a human bone. Their discovery leads the town's new sheriff, Frank Richards (Dean Cain), to reopen an investigation of the unsolved murders of three black men. As he doggedly pursues the case, however, he learns that most of the townspeople would prefer the truth stay hidden. With each new clue, disturbing new facts surface, making the sheriff more determined to see justice prevail. As the case threatens to split the town apart, Sonny and Luke feel pressured to confirm to the segregated ways of the past. Luke is, however, unrelenting in his conviction that skin color is no barrier to lifelong friends. Tensions rise and Sonny discovers he has become the main suspect in yet one more murder. A highly charged trial ensues, polarizing a town that refuses to acknowledge its past. The Runaway is a stirring story of how friendship, determination, and conviction can generate racial change in one heart or an entire town.