I saw an interview with Susan Sarandon, and she said that "Thelma and Louise isn't about feminism, it's about human liberation." I completely agree.
If you put the sexual politics aside, what you have is a story of two human beings who have spent their whole lives being oppressed and controlled by other people. Louise (Sarandon) is a waitress with a tragic past and an unreliable boyfriend. Thelma is a housewife with an arrogant, controlling husband. The two decide to embark on an impromptu vacation, but while stopping for a couple of drinks at a redneck nightclub, Thelma is almost raped by a lecherous customer, and Louise shoots and kills him in the parking lot. Instead of going to the police, the two decide to skip the country and head to Mexico, but a string of unfortunate events forces the two to commit even more crimes, turning them into bona fide fugitives and outlaws.
Strangely, what the two characters discover is that their new lives as outlaws are more satisfying than the stifled lives they led before. At the end of the film, the two make a choice to remain free and never surrender, despite the consequences.
This film asks the question: is the only way to be free in our society to be an outlaw? The answer just might be yes.