I consider this movie a breakthrough. It is the first I've seen that equals - or passes - good live-action movies for subtle development and interaction of characters.
It took the first 30-45 minutes to get going, but that time was used to establish the characters and the setting. Be patient - it's worth the wait. After that, the movie is really about families. I don't mean the "Leave it to Beaver" kind, with Mom, Dad, and their children by each other. I mean the real families these days, where the ideas of Mom and Dad need to flex and where the children are unrelated to one or both. I mean a real family with real problems, holding together because everyone is struggling to hold it together.
The animation is good and the character animation are very good, but excellence is the norm these days. The plot and story are what make this movie stand out. As an aside, I was interested to hear a few English words adopted into the Japanese idiom, "homeless" and "godfather" being the most obvious. I was also interested to see that the Spanish speech wasn't subtitled - English speakers will need to puzzle it through, same as the Japanese listeners did.
This isn't an "adult" movie, but there's not a lot here for kids. That's fine. Kids have their own movies, and we need ours.