Ok, granted this is not a thinker, but it's one of the funniest movies I've seen in a long time. The comparisons to Animal House etc are a little bit off, I think. The humor is really more of a modern variant, sort of dry with clever timing. Picture Wes Anderson (Rushmore, The Royal Tennenbaums) and the Coen brothers (the Big Lebowski, Fargo) getting falling-down drunk.
The three main chacters are all excellent. Luke Wilson plays the likable straight-man, with some of the more subtle humor of the movie (I use 'subtle' in a relative sense) as he responds to all the absurdity. Vince Vaughn is beautifully ridiculous as the mover and shaker of the frat. To make a fight club analogy, he is the proactive Brad Pitt to Wilson's reactive Edward Norton. Will Ferrell is also at his best - a wonderful loser, making us simultaneously cringe and laugh as he blunders through his life.
There is perhaps a little too much emphasis on the plot, which is pretty much the standard for a college movie (the evil dean is trying to get rid of the fun people). But I suppose a little plot is necessary, even in a film like this.

This book is extremely readable, and hard to put down. The authors make a very compelling case for the usefulness of a evolutionary perspective in medicine. I have a couple minor complaints (but don't let this discourage you). The authors seem to move freely between fact and speculation, without making clear distinctions. Not a problem if you're paying attention, but they may sometimes give the impression that their is more data to support a contention than there actually is. Anyway, I highly recommend this book - it's easy to read, stimulating, and bound to make you look at illness and health in a new way.