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Jennifer A. Doudna
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A Crack In Creation: A Nobel Prize Winner's Insight into the Future of Genetic Engineering Kindle Edition

by Jennifer A. Doudna (Author), Samuel H. Sternberg (Author) Format: Kindle Edition
4.6 out of 5 stars 2,022 ratings
4.1 on Goodreads
6,414 ratings
BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY | Finalist for the Los Angeles Times Book Prize

“A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books

Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life.

“The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas

“An invaluable account . . . We owe Doudna several times over.” — Guardian
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  1. Print length
    307 pages
  2. Language
    English
  3. Publisher
    Mariner Books
  4. Accessibility
    Learn more
  5. Publication date
    June 13 2017
  6. File size
    16.5 MB
  7. Page Flip
    Enabled
  8. Word Wise
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  9. Enhanced typesetting
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  1. A full 8 percent of the human genome—over 250 million letters of DNA—is a remnant of ancient retroviruses that infected ancestors of our species millennia ago.
    Highlighted by 1,184 Kindle readers
  2. The human genome comprises about 3.2 billion letters of DNA, with around 21,000 protein-coding genes.
    Highlighted by 1,148 Kindle readers
  3. As long as the genetic code for a particular trait is known, scientists can use CRISPR to insert, edit, or delete the associated gene in virtually any living plant’s or animal’s genome.
    Highlighted by 1,133 Kindle readers
  4. Inspired in part by the uncanny ability of viruses to splice new genetic information into the DNA of bacterial cells, the pioneers of this early gene therapy realized they could use viruses to deliver therapeutic genes to humans.
    Highlighted by 922 Kindle readers
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From the Publisher

a crack in creation

Product details

  • ASIN ‏ : ‎ B01I4FPNNQ
  • Publisher ‏ : ‎ Mariner Books
  • Accessibility ‏ : ‎ Learn more
  • Publication date ‏ : ‎ June 13 2017
  • Edition ‏ : ‎ Illustrated
  • Language ‏ : ‎ English
  • File size ‏ : ‎ 16.5 MB
  • Screen Reader ‏ : ‎ Supported
  • Enhanced typesetting ‏ : ‎ Enabled
  • X-Ray ‏ : ‎ Enabled
  • Word Wise ‏ : ‎ Enabled
  • Print length ‏ : ‎ 307 pages
  • ISBN-10 ‏ : ‎ 9780544716940
  • ISBN-13 ‏ : ‎ 978-0544716964
  • Page Flip ‏ : ‎ Enabled
  • Best Sellers Rank: #244,148 in Kindle Store (See Top 100 in Kindle Store)
  • Customer Reviews:
    4.6 out of 5 stars 2,022 ratings

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  1. Jennifer A. Doudna

    Jennifer A. Doudna

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  2. Samuel H. Sternberg

    Samuel H. Sternberg

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    DR. SAMUEL H. STERNBERG is a protein-RNA biochemist and author of numerous high‑profile scientific publications on CRISPR technology. He runs a research laboratory at Columbia University, where he is assistant professor in the Department of Biochemistry and Molecular Biophysics. He lives in New York City.

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