Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition Hardcover – Jan 10 2011
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About the Author
Laurence L. Brunton, PhD<br>Professor of Pharmacology and Medicine<br>University of California, San Diego<p>Laurence Brunton trained under Alfred Goodman-Gilman and is nationally recognized for his expertise in cell signaling and cardivacular pharmacology. He has published more than 200 original research papers.
Bruce Chabner, MD Professor of Medicine Harvard Medical School Director, Massachusetts General Hospital Cancer Center Boston, MA
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Most Helpful Customer Reviews on Amazon.com (beta)
This is a 2000 page book, and goes into excruciating detail to the point where the grand scheme is lost. Moreover, the excruciating detail is not well explained, or starts out well explained and abruptly digresses before the explanation's conclusion. The cardiac action potential is one such example.
As an instructional aide, it is very poor. It is very difficult to learn from this book, and some explanations are wrong. As an example, an this book describes an inverse agonist as a type of regulatory ligand that stabilizes a receptor in its inactive form, which is incorrect. It should be described as a type of regulatory ligand that reduces activity below a receptor's basal rate.
There are numerous errors in page layout that affect the way the outline of the material is perceived. As an example, in the general principles section where the physiological receptors are presented, there is a nice table showing the various types of receptors. The body of the text does not unfold as expected. I will use an outline format as an analogy. A proper presentation would unfold as such:
C. nuclear receptor
What we get instead is:
I. nuclear receptor
The headings are completely screwed up. Nuclear receptor looks like a new section in the chapter.
Also, the book goes back and forth between regular print and microscopic print in the body of the text. And the microscopic print is smaller than image and table captions.
Finally, the index is terrible. It has many key omissions that are inexcusable for a book in its 12 edition. NMDA receptors are an important class of receptors, and it is described with illustrations in the chapter on the CNS, but NMDA receptors are nowhere to be found in the index.
The illustrations are beautiful, but are far too large, requiring the explanation to be on adjacent pages, requiring one to flip back and forth. As an aside, the high quality images are why I give this book 3/5 rather than 2/5.
So I guess it's clear that I don't like this book, and am returning it.
That being said, there is one quirk that I wish McGraw Hill would fix. With at least two editions I've owned, including the current one, there is an annoying, unexplained switch from a normal font to a very small font. The small font seems to come on without warning, and for my eyes it is very difficult to read. This morning, for example, I was reviewing digoxin. The introductory paragraphs were easy to read, but for unknown reasons the section on adverse effects (and the section following that) was in the small print. Why would you want to make something this important more difficult to read? This change to small font occurs seemingly randomly throughout the text, and is extremely aggravating.
As I age, I will continue to go to Goodman and Gilman for reference, but I hope as my eyes age future editions will eschew this exasperating practice of tiny fonts.